教育经历：

2014.09-2020.07 工学博士 河北工业大学

2010.09-2014.07 理学学士 长治学院

 工作经历：

2020.10至今    校聘研究员，我校

 奖励荣誉：

2020年，河北省优秀博士论文

 执教课程：

本科生《细胞生物学》，《细胞生物学实验》；研究生《细胞生物学研究进展》

【科研领域】

TMEM16A离子通道结构与功能关系，TMEM16A离子通道靶向药物分子设计

【科研项目】

1. 国家自然科学基金，82104224，2022/01-2024/12，主持；

2.  河北省自然科学基金，C2021201025，2021/12-2023/12，主持；

3.  中国博士后科学基金面上项目，2022M710998，2022/1-2023/12，主持；

4.  河北省博士后择优资助重点项目，B2022005012，2022/1-2023/12，主持；

【代表性论文】

1.  Sun, W.^#, Guo, S.^#(共同一作), Li, Y.^#, et al. Anoctamin 1 controls bone resorption by coupling Cl− channel activation with RANKL-RANK signaling transduction[J], Nature Communications, 2022, 13(1):2899.

2.  Bai, X., Liu, X., Li, S., An, H., Kang, X., Guo, S.*. Caffeic Acid, an Active Ingredient in Coffee, Combines with DOX for Multitarget Combination Therapy of Lung Cancer[J], Journal of Agricultural and Food Chemistry, 2022, 70(27):8326-8337.

3.  Guo, S., Bai, X., Shi, S., et al. Multi-target tracheloside and doxorubicin combined treatment of lung adenocarcinoma[J], Biomedicine & pharmacotherapy, 2022, 153:113392.

4.  Bai, X., Li, S., Liu, X., An, H., Kang, X., Guo, S.*. Nuciferine Inhibits TMEM16A in Dietary Adjuvant Therapy for Lung Cancer[J], Journal of Agricultural and Food Chemistry, 2022, 70(12):3687-3696.

5.  Chang, L., Chang, R., Shen J., Wang, Y., Song, H., Kang, X., Zhao. Y., Guo, S.*, Qin, J*. Self-healing pectin/cellulose hydrogel loaded with limonin as TMEM16A inhibitor for lung adenocarcinoma treatment[ J]. International Journal of Biological Macromolecules, 2022, 219: 754-766.

6.  Guo, S., Bai, X., Shi, S., et al. TMEM16A, a homoharringtonine receptor, as a potential endogenic target for lung cancer treatment[J], International Journal of Molecular Sciences, 2021, 22(20):10930.

7.  Guo, S., Bai, X., Liu, Y.F., et al. Inhibition of TMEM16A by natural product silibinin: potential lead compounds for treatment of lung adenocarcinoma[J], Frontiers in Pharmacology, 2021, 12: 643489.

8.  Guo, S., Chen, Y.F., Shi, S., et al. Arctigenin, a novel TMEM16A inhibitor for lung adenocarcinoma therapy[J], Pharmacological Research, 2020, 155: 104721.

9.  Guo, S., Chen, Y.F., Shi, S., et al. The molecular mechanism of ginsenoside analogs activating TMEM16A[J], Biophysical Journal, 2020, 118(1): 262-272.

10.  Guo, S., Qiu, L., Chen, Y.F., et al. TMEM16A-inhibitor loaded pH-responsive nanoparticles: a novel dual-targeting antitumor therapy for lung adenocarcinoma[J], Biochemical Pharmacology, 2020,178:114062.

11.  Guo, S., Wang, H., Pang, C.L., et al. Entering the spotlight: chitosan oligosaccharides as novel activators of CaCCs/TMEM16A[J], Pharmacological Research, 2019, 146: 104323.

12.  Guo, S., Chen, Y.F., Pang, C.L., et al. Matrine is a novel inhibitor of the TMEM16A chloride channel with antilung adenocarcinoma effects[J], Journal of Cellular Physiology, 2019, 234(6): 8698-8708.

13.  Guo, S., Chen, Y.F., Pang, C.L., et al. Ginsenoside Rb1, a novel activator of the TMEM16A chloride channel, augments the contraction of guinea pig ileum[J], Pflugers Archiv : European Journal of Physiology, 2017, 469(5-6): 681-692.

14.  Hao, A.Q.^#, Guo, S.^#(共同一作), Shi, S., et al. Emerging modulators of TMEM16A and their therapeutic potential[J], The Journal of Membrane Biology, 2021, 254(4): 353-365.

15. Huang, Y.Y.^#, Guo, S.^#(共同一作), Ren, S.X., et al. The natural compound cinnamaldehyde is a novel activator of calcium-activated chloride channel[J], The Journal of Membrane Biology, 2018, 251(5-6): 747-756.3.