郭蕊，哲学博士（Ph.D.），毕业于美国怀俄明大学生物医学科学专业。2018年12月全职引进我校，现任太阳成集团tyc138教授，博士生导师，学院学位委员会委员。河北省特聘专家，美国心脏学会（AHA）会员，美国糖尿病学会（ADA）会员，美国实验生物学会（EB）会员，中国细胞生物学学会会员，中国生物物理学学会会员。2017年度国家优秀自费留学生获得者与发言人。2019年协助组建了干细胞与生物医学实验室。主要研究方向为代谢生物学与心血管疾病的分子机制研究，疾病标志物的筛选，疾病预测、诊断与治疗方案的研究，其中在自噬的信号传导、组织蛋白酶与代谢性心脏病的调节机制等方面有深入研究。至今在国际知名期刊Autophagy，Cardiovascular Research，European Heart Journal，Acta Physiologica，Circulation，Diabetes等发表论文及国际顶会摘要近50篇，引用频次过千，i10指数24。担任多种国际期刊客座编辑和期刊评委。2018年底回国后，获批并主持两项国家自然科学基金，一项河北省自然科学基金，两项河北省高层次人才资助项目。

【执教课程】

o  生物工程专业外语（本科生，必修，2019-2021）

o  细胞生物学（本科生，必修）

o  细胞生物学实验（本科生，必修）

o  研究生专业外语（研究生，必修，2019）

o  研究生专业英语与科技论文写作（研究生，必修，2020）

o  生命科学前沿进展（研究生，必修）

o  细胞生物学研究进展（研究生，专业选修）

o  生物医药技术与研究进展（研究生，专业选修）

【科研领域】

o  代谢性心血管疾病的分子机制及治疗靶标的研究

•      酒精性心肌病的代谢机制

•      糖尿病性心血管疾病的代谢机制

•      环境毒性对人体代谢功能的影响与分子机制

•      干细胞分化与代谢机制

•      肿瘤心脏病学与代谢机制

•      干细胞与外泌体在糖尿病并发症和心血管疾病中的研究与应用

o  细胞代谢、细胞自噬、线粒体功能、代谢组学、蛋白质翻译后修饰等在心血管疾病、糖尿病和肿瘤发生发展中的作用机制和病理生理学意义

o  其他代谢性疾病的发生机制和靶标研究

【荣誉奖励】

o  2021.10：微课《普通光学显微镜的结构与使用》在河北省教育教学信息化交流活动评选中获得一等奖。

o  2021.12：微课《普通光学显微镜的结构与使用》入选全国教师教育信息化交流活动高等教育组微课研讨作品。

o  2022.6：指导2022届我校本科生毕业论文优秀指导奖。

o  2022.8：指导全国大学生生命科学竞赛获得全国二等奖。

1.      Chen Y, Yang J, Wang Y, Shen W, Liu J, Yuan M, Hao X, Zhong L, Guo R*. Identification and Analysis of Hub Genes in Diabetic Cardiomyopathy: Potential Role of Cytochrome P450 1A1 in Mitochondrial Metabolism and STZ-Induced Myocardial Dysfunction. Front. Cardiovasc. Med. 21 March 2022: Vol 9:835244.

2.      Zhao M, Lian A, Zhong L, Guo R*. The Regulatory Mechanism Between Lysosomes and Mitochondria in the Aetiology of Cardiovascular Diseases. Acta Physiologica. 2022 Feb; 234(2):e13757.

3.      李沛轩, 钟理, 郭蕊*. 重金属镉致心血管疾病的潜在机制及治疗对策. 中国科学: 生命科学, 2021, 51(9). Li P X, Zhong L, Guo R. Potential mechanism and treatment of heavy metal cadmium-induced cardiovascular disease (in Chinese). Sci Sin Vitae, 2021,51(9), doi: 10.1360/SSV-2021-0226.

4.      李钰, 赵倩倩, 梁胜贤, 钟理，郭蕊*. TFEB与线粒体稳态在脓毒症并发症中的调控机制. 中国科学: 生命科学, 2021, 51(9),. Li Y, Zhao Q Q, Liang S X, et al. Regulation of TFEB and mitochondrial homeostasis during sepsis complications (in Chinese). Sci Sin Vitae, 2021, 51(9), doi: 10.1360/SSV-2021-0213.

5.      Lochner A, Wang H, Reiter R, Guo R, Zhou H. Editorial: Role of Mitochondrial Quality Control in Myocardial and Microvascular Physiology and Pathophysiology. Front. Physiol., 08 September 2021. Volume 12, Article 745033.

6.      Liang G, Sun J, Liu Y, Liu D, Liang S, Guo R, Zhong L. Identification of tumor associated genes using transcriptome analysis. Cancer Research, July 2021, 81 (13_Suppl): Abstract nr 2312.

7.      Liu J, Zhong L, Guo R*. The Role of Posttranslational Modification and Mitochondrial Quality Control in Cardiovascular Diseases. Oxidative Medicine and Cellular Longevity. Feb 2021: 6635836.

8.      Yang H, Heyer J, Zhao H, Liang S, Guo R*, Zhong L*. The Potential Role of Cathepsin K in Non-Small Cell Lung Cancer. Molecules. Aug 2020, 25(18): 4136.

9.      Zhao H, Yang H, Sun J, Liang G, Zhao Q, Zhang X, Liang S, Guo R and Zhong L. Mesenchymal stem cells promote PD-L1 expression in lung cancer cells. Cancer Research, Aug 2020, 80 (16) Supplement: a6011.

10.   Guo R*, Yang H, Zhang Y, Li B, Liu X, Zhong L. The Potential Clinical Role of Cathepsin K and Autophagy in the Prevention of Alcoholic Cardiomyopathy. Circulation 2019, 140 (Supplement 1): a15085.

11.   Guo R, Wang Q, Nair R, Barnes S, Smith D, Dai B, Robinson T, Nair S: Furosap, a novel Fenugreek seed extract improves lean body mass and serum testosterone in a randomized, placebo-controlled, double blind clinical investigation. Functional Foods in Health and Disease. Nov 2018; 8(11): 508-519. 

12.   Guo R, Hua Y, Ren J, Bornfeldt K, Nair S: Cardiomyocyte-Specific Disruption of Cathepsin K Protects Against Doxorubicin-Induced Cardiotoxicity. Cell death & disease. Jun 2018, 9: 692.

13.   Guo R, Nair S. Role of MicroRNA in Diabetic Cardiomyopathy: from Mechanism to Intervention. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2017, 1863(8):2070-2077.

14.   Guo R, Hua Y, Rogers, O, Ren J, Nair S. Cathepsin K knockout protects against cardiac dysfunction in diabetic mice. Scientific Reports. Aug. 2017, 7(1):8703.

15.   Guo R, Rogers O, Nair S. Targeting Apelinergic System in Cardiometabolic Disease. Current drug targets. 2017;18(15):1785-1791.

16.   Guo R, Ren J, Nair S. Cathepsin K Knockout Inhibits Calcification, Migration and Proliferation of Aortic Vascular Smooth Muscle Cells. Circulation 2017, 136 (Supplement 1).

17.   Guo R, Nair S, Ren J. Role of the Cathepsin K/Calcineurin/NFATs Axis in the Pathogenesis and Management of Diabetic Cardiomyopathy. Cardiology Plus. 2016, 1(3).

18.   Guo R, Hua Y, Ren J, Bornfeldt K, Nair S. Cardiomyocyte-Specific Deletion of Cathepsin K Protects Against Doxorubicin-Induced Cardiac Dysfunction. Circulation 2016, 134 (Supplement 1).

19.   Guo R, Hua Y, Rogers O, Ren J, Nair S. Cathepsin K knockout Preserves Cardiac Function in Diabetic Mice: Role of Calcineurin/NFAT Signaling. Diabetes 2016, 65 (Supplement 1): A101-A169.

20.   Guo R, Zhang Y, Turdi S, Ren J：Adiponectin Knockout Accentuates High Fat Diet-Induced Obesity and Cardiac Dysfunction: Role of Autophagy. Biochim Biophys Acta. 2013, 1832(8):1136-1148.  

21.   Jiang S*, Guo R*, Zhang Y, Zuo Y, Ren J: Heavy Metal Scavenger Metallothionein Mitigates Deep Hypothermia-Induced Myocardial Contractile Anomalies: Role of Autophagy. Am J Physiol Endocrinol Metab. 2013, 304(1):e74-86.

22.   Guo R, Hu N, Kandadi M, Ren J: Facilitated ethanol metabolism promotes cardiomyocyte contractile dysfunction through autophagy in murine Hearts. Autophagy. 2012, 8(4):593-608

23.   Guo R, Ren J: Deficiency in AMPK attenuates ethanol-induced cardiac contractile dysfunction through inhibition of autophagosome formation. Cardiovasc Res. 2012, 94(3):480-491.

24.   Guo R, Ren J. Aldehyde Dehydrogenase-2 (ALDH2) Ameliorates Chronic Alcohol Ingestion-Induced Hepatic Steatosis and Inflammation. Experimental Biology Annual Scientific Meeting, San Diego Convention Center, San Diego, CA, Apr. 21-25, 2012; ORAL presentation. The FASEB Journal 2012, 26 (1), Supplement 405.8.

25.   Ge W, Guo R, Ren J: AMP-dependent kinase and autophagic flux are involved in aldehyde dehydrogenase-2-offered protection against cardiac toxicity of ethanol. Free Radic Biol Med. 2011, 51(9):1736-1748.

26.   Ma H, Guo R, Yu L, Zhang Y, Ren J: Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde. Eur Heart J. 2011, 32(8):1025-1038.

27.   Guo R, Ren J: Alcohol and acetaldehyde in public health: from marvel to menace. Int J Environ Res Public Health. 2010, 7(4):1285-1301.

28.   Guo R, Ma H, Gao F, Zhong L, Ren J: Metallothionein alleviates oxidative stress-induced endoplasmic reticulum stress and myocardial dysfunction. J Mol Cell Cardiol. 2009, 47(2):228-237.

【书籍章节发表】

1.    Guo R, Nair S. Protease Cathepsins in Cardiomyopathy: from Mechanism to Intervention. Proteases in human Diseases. p.447. Chapter 21. Springer Nature. 2017. DOI 10.1007/978-981-10-3162-5_21.

【教材出版】

1.    《细胞生物学实验教程（第二版）》（ISBN：978-7-03-071320-9），科学出版社，2022.10.

【研究团队】

    干细胞与生物医学研究实验室，细胞代谢与心血管疾病研究团队：郭蕊教授课题组是太阳成集团tyc138唯一一支以细胞代谢和心血管并发症为主的研究团队，每年在细胞生物学专业（学硕）和生物与医药专业（专硕）招生，期待本科为基础医学、生理病理学、生物化学、细胞生物学、分子生物学、生物信息学、组学等相关专业优秀学子的加入。同时也欢迎代谢生物学与心血管疾病等相关领域的博士、博士后加入我们的团队。